ea0089b5 | Basic Science | NANETS2022
Hallenbeck Paul L.
, Chada Sunil
, Sankar Neil
, Chauhan Aman
Background: Oncolytic viruses (OV) hold potential for not only delivering durable anti-tumor responses but also converting immunologically cold tumors to hot tumors. Seneca Valley Virus (SVV-001) is a naturally occurring oncolytic picornavirus found to have selectivity for tumor cells with neuroendocrine (NE) properties. Because of the paucity of syngeneic murine NE tumor models, we evaluated the efficacy of Seneca Valley Virus (SVV), in combination wit...